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Pericarditis: Symptoms and treatment Pericarditis is simply the inflammation of the pericardium, two layers of tissue that surround the heart muscle. there are many causes, most are unknown, but here are the most common causes: 1. Idiopathic which are minor viral illnesses or a cold 2. Injury to the heart, such as a heart attack(myocardial infarction), complications of heart surgery or physical trauma 3. Infection, the main causes Viral,Fungal,HIV 4. Tumors or Cancer such as primary tumors in the heart or pericardial area and Metastatic which plainly means a cancer in another part of the b...