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What is Primary Osteoarthritis?

Osteoarthritis is classified as primary (idiopathic) when the exact cause is unknown, and secondary if it is associated with a specific disease or condition such as diabetes. Most primary OA is related to aging. Approximately 80-90 percent of men and women have evidence of OA by the time they reach age 65.

In the vast majority of cases, OA develops silently before causing noticeable pain and stiffness. Affected individuals often do not have any symptoms until after age 50.

How do joint injuries result in OA?

Chondrocytes are cells in the joint that produce cartilage. They normally die off (apoptosis) at a rate of less than 1 percent. But within 48 hours of trauma to a joint, the cell death rate shoots up dramatically-sometimes as high as 37 percent. The dying cells stimulate the release of enzymes that destroy cartilage, which in turn can lead to arthritis.

What are the symptoms of OA?

Pain is the most frequent symptom of OA. Other common symptoms are morning stiffness in the joint, limited range of movement, and crepitus (a crackling sound or feeling) when the joint is moved.

The pain of osteoarthritis is described as a sharp ache or burning sensation that worsens with use. Pain increases as cartilage erodes and bone surfaces lose their protection. The chronic pain and stiffness leads to decreased movement, which in turn allows the muscles to atrophy and ligaments to become lax.

What causes osteoarthritis?
In OA, biochemical and metabolic changes in the body result in the breakdown of joint cartilage. Over time, the joint cartilage wears away and bony growths (osteophytes) may form at the edges of joints. The cartilage loses its ability to effectively cushion the area between the two bones, and osteophytes may press on surrounding tissue. This results in pain that may range from mild to disabling.

How many types of Arthritis are there?

Researchers have identified more than 100 different types of arthritis. The most common are osteoarthritis, rheumatoid arthritis, and gout.

What is osteoarthritis?

The most common type of arthritis, osteoarthritis (OA) is generally associated with aging and joint wear and tear. It can also result from other disorders such as diabetes. OA affects many joints, from the large, weight-bearing joints of the hips and knees to the smaller joints of the spine, hands, feet, and shoulders.

What is rheumatoid arthritis?

Rheumatoid arthritis (RA) is a long-lasting disease where the immune system-the body's defense against

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