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Understanding the Human Genome Project

by Janette Peel

Created on: May 27, 2009

Locked inside your body, amongst the tiny strands of DNA are the secrets of what makes you who you are; your body, your life and your personality.

The human genome is the complete description of every one of the genes that you carry within you, and your body contains about 20,000-25,000 of them. Basically, the human genome is a kind of genetic instruction manual for building a human being.

It is inaccurate to speak of 'the' human genome, as every human genome is different, but not by much. Your genes are 99.9 per cent the same as everyone else's but that crucial 0.1 per cent difference is what makes you an individual.

To know your genome would be like finding out what characteristics you have inherited from your parents before you have even grown up. You would be able to tell what you will look like, what diseases you are most at risk from and, to an extent, how you will behave and even when you might die.

Mapping the genome was a worldwide project. The Human Genome Project was the largest ever international collaboration in biology. It was coordinated by the US Department of Energy and the National Institutes of Health and combined the efforts of researchers from countries including the UK, Germany, France and Japan. It main purpose was to work out the sequence of all three billion letters in human DNA and to label the precise whereabouts and function of each gene.

Secondary goals were to store this information, transfer the technologies to the private sector for medical applications and address ethical, legal and social issues. Launched October 1990, the project was planned to last 15 years, but advancements in technology accelerated its completion. In June 2000 it was announced that the first working draft of the human genome was complete. The scientists completed a high-quality, finished sequence in 2003.

The complicated process of mapping the many thousands of genes in the human body took much time and many scientists, but what will its completion mean?

The human genome is made up of a chemical called deoxyribonucleic acid, or DNA, which is bundled up in the nucleus of every one of the 100 trillion cells in the human body. For the most part DNA doesn't appear to do anything apart from replicate itself. In fact, 97 per cent of human DNA is meaningless and is called junk DNA by scientists.

One here and there along strands of DNA do you find the genes that determine how an individual will develop.

DNA has four basic components, called bases, and

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