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Created on: August 16, 2008
Breast cancer and cancer in other tissues and organs is caused by the same mechanism, but there are certain anatomical, microanatomical, physiological, and environmental factors that exacerbate the underlying cause of cancer so certain tissues such as bone marrow, lymph nodes, and epithelium (skin,cervix and vaginal surface,and vocal cords), which feature rapidly dividing cells, endothelium, which also features rapidly dividing cells(inside lining of the large intestine, esophagus, stomach, pharynx, lung, bronchal tubes, uterus, breast tubules), tissue with high blood flow (thyroid, brain, breast acini (the secretory units of the breast) and tubules, prostate, ovaries), tissue with paristaltic function (colon, pancreatic duct, bile ducts, esophagus, stomach), tissues which frequently feature low-grade, non-symtomatic infection (cervix, uterus, pharynx, larynx, vocal cords, stomach, colon), organs which feature frequent chemical irritation (bronchial tubes, lungs, lung pleura, pharynx, and esophagus). Tissues which feature exposure to ultra-violet radiation (skin). Those tissues which feature a combination of the above exacerbative structures, physiological function (paristalsis) or external conditions, such as the colon and lung feature an increased frequency of cancer. Tissues that have a great many microanatomical structures such as the breast will feature more frequent cancer development from a statistical aspect.
It is rare to have cancer, for instance, in the tissues of tendons and muscles since those tissues do not feature rapid cell division as do cells of the epitheleum and endothelium, both explained above.
The female breast features a great number of small structures that have a great amount of blood flow since the production of mammary milk reqires such a flow. Even in the non-pregnant female the vascular network in the breast acini and tubule structures features a dense capillary network. Men have very few breast acini compared to women and therefore male breast cancer is quite rare although I have had two cases in my clinics. The growth of the breast secretory units are influenced by estrogen so it is natural for breast cancer cells to be stimulated by estrogen and multiply faster. It is reasonably common for a woman who has breast cancer in one breast to develop it in the other due to the high-grade exacerbating situation in both breasts and the fact that the underlying disease process is likely to be of a higher grade in a patient who develops
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